The Precision Medicine Challenge for Hospital Providers

PRECISION MEDICINE is a biomedical BIG-Data challenge

The medical and hospital community is facing a paradigm-shift: Medicine is becoming molecular & digital. More and more empowered patients are demanding their medical doctors and hospital providers to offer a complete range of treatment options, including new molecular diagnostics and therapies. In parallel the genomic revolution in medicine offers a new set of diagnostics and individually tailored therapies. Since 2016 next-generation sequencing (NGS) is available for about $1,000 per genome. Empowered patients recognize that whole-genome sequencing is now affordable, as many routine medical tests, and it’s becoming increasingly available. Patients want the best medical outcome possible. Empowered Patients understand the value of molecular diagnostics for their individualized therapies to optimize their value-based outcome. They will ask your hospital to deliver precision medicine.

The future of medicine is at the fingertips of hospital providers when they understand to become a central hub in the precision medicine value-chain.

Hospital providers today face the challenges of a fundamental paradigm-shift from an observational and cellular-based IT-supported imprecision medicine to an IT-centered scientific molecular based precision medicine


the transformation from a traditional, hierarchical and fragmented silo-medicine towards a molecularized, digitalized and „democratized“ Medicine with an empowered patient accessing information by using more than 3 billion (medicalized) smartphones being equally or even better informed than the MD`s in your hospital system.

Right now, most medical treatments are designed for the average statistical patient – called the traditional „one-fits-many“ concept of the pharaceutical industry. Precision medicine, on the other hand, analysis each patients disease on its molecular level to define the best individual treatment to optimize the value-based outcome for each patient.

The „one-fits-many“-Concept has no future – but hospitals are still delivering Imprecision Medicine:

Hospitals need to navigate through big molecular and medical data based on individual and cohort analysis to find the best and safest treatment based on the individual molecularity for each of their patients to deliver optimal value and outcome for their patients and the hospital.

Source: 610 / Nature / VOL 520 / 30 APRIL 2015


The Big-Data Challenge

First individual molecular diagnosis and analysis to define the value-based cancer treatment for each patient: PRECISION MEDICINE FIRST.

Precision Medcine is an integration and interpretation challenge to be addressed and solved together by an synchronized hospital provider network for precision medicine: The PMA PRECISION MEDICINE HOSPITAL NETWORK

  • Sequencing one human genome generates about 200 gigabytes
  • Each cancer is molecularly different, each patient has an individual molecular cancer disease
  • Countless drug combinations and co-medications
  • Complex co-morbidities
  • Complex medical conditions
  • The non-responder problem
  • Adverse drug effects and drug side effects
  • Molecular diesease matching in pharmagenomics with tousends approved medications
  • Navigating the individual patient by matching thousands of clinical studies
  • Millions of scientific publications can`t be analyzed by the medical doctors to optimize every unique case, which publication is valuable can`t any more be judged by the MD`s alone


The Precision Medicine Value-Chain:


Executive Summary for Hospital Providers

The case-specific costs p.a. in your hospital will decline in the course of the introduction of precision medicine.

Better individual efficacy due to molecular diagnostic with pharmocogentic matching delivering higher safety, precise medication, lower risk profile,  better management and higher ethical standards for the treatment of individual diseases in your hospital. All in all, shorter lay-up times and / or treatment duration. Leading to growing patient numbers for the hospital on a regional level by applying modern medicine in your precision medicine center.

Precision medicine delivers also new precise study designs in molecularly profiled population studies. This will not only make studies faster and cheaper, but also generate longer patent times. Clinical precision medicine centers contribute directly to the hospitals value creation by generating additional income outside the covered, restricted budget framework by integrating the hospital into our PMA-knowledge-network. Pharmaceutical innovations can be amortized more favorably and in consequence to falling drug prices. Additional revenues to generate higher income for the hospital industry.

Summary: The case-specific costs per treatment will decrease.

Advantage: There will be more hospital cases for you, as diseases such as cancer become quasi-chronic and also the survival will increase significantly.

Active hospital providers in our PMA-Knowledge-Network can be the winners of the transformation towards precision medicine. Our goal is to achieve economies of scale in quality and technology by collaboration.